Our results demonstrate that offspring of maternal alcohol exposure, together with maternal taurine supplementation show conserved learning and memory, while that of offspring treated taurine later in life are disturbed. Adult offspring is supplemented taurine to verify its ability to reverse damages on learning and memory through a water maze task performance. Pregnancy outcomes, offspring mortality and successive bodyweight until adult were monitored. The experimental protocol was conducted using ICR-outbred pregnant mice given 10 % alcohol, with or without maternal taurine supplementation during gestation and lactation. This study aims to investigate protective roles of taurine against maternal alcohol consumption on growth and development of offspring. However, it is still unknown whether taurine can exert its protection during development of central nervous system and whether it can reverse alcohol damages on developed brain later in life. Taurine, a sulfur-containing amino acid, is essential during development, and continually found to be protective against neurotoxicity and various tissue damages including those from alcohol exposure. Maternal alcohol consumption is known to affect offspring growth and development, including growth deficits, physical anomalies, impaired brain functions and behavioral disturbances. Protective role of taurine in developing offspring affected by maternal alcohol consumptionĪnanchaipatana-Auitragoon, Pilant Ananchaipatana-Auitragoon, Yutthana Siripornpanich, Vorasith Kotchabhakdi, Naiphinich These data suggest that maternal taurine supplementation may Despite protective effects of taurine in MOT offspring, neonatal mortality was increased in CT neonates, indicating possible adverse effects of taurine in the setting of normal pregnancy. Conversely, a pro-inflammatory phenotype was observed in MOT mothers suggesting a possible maternal trade-off to protect the neonate. MO neonates displayed a pro-inflammatory hepatic profile which was partially rescued in MOT offspring. Both MO and MOT mothers displayed evidence of fatty liver accompanied by alterations in key markers of hepatic lipid metabolism. Taurine normalised maternal plasma TNF-α and glutamate concentrations in MOT animals. A MO diet resulted in maternal hyperinsulinemia and hyperleptinemia and increased plasma glucose, glutamate and TNF-α concentrations. Maternal and neonatal weights, plasma cytokines and hepatic gene expression were analysed. Time-mated Wistar rats were randomised to either: 1) control : control diet during pregnancy and lactation (CON) 2) CON supplemented with 1.5% taurine in drinking water (CT) 3) maternal obesogenic diet (high fat, high fructose) during pregnancy and lactation (MO) or 4) MO supplemented with taurine (MOT). Using a model of maternal obesity, we examined the effects of maternal taurine supplementation on outcomes related to inflammation and lipid metabolism in mothers and neonates. Further, the efficacy of taurine supplementation in the setting of maternal obesity is not known. The effects of taurine in mediating inflammatory processes as a protective mechanism has not been investigated. Following maternal undernutrition, taurine supplementation can improve outcomes in offspring, possibly via effects on glucose homeostasis and insulin secretion. However, intervention strategies to reverse or ameliorate the effects of maternal obesity on offspring health are limited. Maternal obesity is associated with obesity and metabolic disorders in offspring. Li, Minglan Reynolds, Clare M Sloboda, Deborah M Gray, Clint Vickers, Mark H Effects of taurine supplementation on hepatic markers of inflammation and lipid metabolism in mothers and offspring in the setting of maternal obesity.
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